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The two-volume set LNCS 3644 and LNCS 3645 constitute the refereed proceedings of the International Conference on Intelligent Computing, ICIC 2005, held in Hefei, China, in August 2005.§The program committee selected 215 carefully revised full papers for presentation in two volumes from over 2000 submissions, based on rigorous peer reviews. The first volume includes all the contributions related with perceptual and pattern recognition, informatics theories and applications computational neuroscience and bioscience, models and methods, and learning systems. The second volume collects the papers related with genomics and proteomics, adaptation and decision making, applications and hardware, and other applications.