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Bilayer Tablet
An Emerging Trend For The Development Of Oral Immediate And Controlled Release Dosage Form
Engels
127 b
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Bilayer tablet is new era for successful development of controlled release formulation along with various features to provide successful drug delivery system. Bilayer tablets can be a primary option to avoid chemical incompatibilities between API by physical separation and to enable the development of different drug release profiles. The manufacture of bilayer tablets produced by sequential compaction of loose powder layers has become of increased interest within the pharmaceutical industry due to the tailored release profiles of active ingredients that may be obtained. Bilayer tablet is suitable for sequential release of two drugs in combination, separate two incompatible substances and also for sustained release tablet. The immediate release layer of bilayer tablet has worked as the loading dose and the sustained release layer has maintained therapeutic plasma drug concentration for prolonged time. Using a modified tablet press may therefore be the best approach in producing a quality bilayer tablet under GMP conditions, especially when high production output is required.
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