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This volume follows on from the symposium 'Brain Machine Interfaces - Implications for science, clinical practice and society', held on August 26th-29th 2010 in Ystad, Sweden, and features contributions from pioneers and leading scientists in the field of BMI and motor systems physiology, including spinal cord, basal ganglia and motor cortex. The wide range of topics covered include implants for mind control of prostheses and in robotics, clinical and experimental research on Deep Brain Stimulation (DBS) for the treatment of Parkinson's disease, depression and Alzheimer's disease, cochlear implants, retinal implants, novel flexible micro- and nano-electrode implants, safety aspects including acute and chronic tissue reactions to implants and on ethical issues in DBS. Program and abstracts from the individual contributors can be found on our associated website. Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research. It includes chapters that are extensively referenced to provide readers with a comprehensive list of resources on the topics covered. All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist.