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The author of this work argues that science and metaphysics are closely and inseparably interwoven in the work of Descartes, such that the metaphysics can't be understood without the science and vice versa. In order to make his case, the author offers a careful philosophical reconstruction of central parts of Descartes' metaphysics and of his theory of perception, each considered in relation to Descartes' epistemology. He aims to show that Descartes gave an important positive role to sense-perception in his epistemology, and also that he used his reflections on sense-perception to frame his criticism of previous theories of the sensory qualities of objects.