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Formulation and Characterization of Diclofenac Sodium Gel
Engels
95 b
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In this present study it can be concluded that topical gel formulations containing drug Diclofenac sodium were prepared with different concentration of gelling agents (carbopol-940/934/ HPMC 3K), which have shown an acceptable results in various evaluation studies. Gel was characterized on basis of various evaluation paeameters, All prepared gel showed acceptable physical properties concerning color, odour, consistency, uniformity, homogeneity, pH value, viscosity and spreadability. An in vitro drug release study was carried out using an egg membrane by using instrument franz's diffusion cell (dolphin).The results indicates that in over 24 hours of total study up to 90.12 % of diclofenac sodium drug is release through the membrane. According to the results obtained from this study, it was concluded that Diclofenac Sodium was successfully incorporated into the carbopol formulation to obtain a gel. F5 gel formulation showed good pH value, conductivity, viscosity, spreadability, and stability before and after the 12 days in the freeze-thaw cycle. Therefore, it was concluded that the formulation F5, could be very promising alternative for the topical or transdermal treatment.
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