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The discovery of the structure and function of DNA and the cracking of the genetic code have led to rapid advances in gene therapy and screening and diagnosis on a molecular basis. While initial therapy has been for patients with single gene defects, there is increasing interest in acquired disease, using the approach to assess or treat cancer. Virtually all tissues are being studied for genetic modification, including bone marrow and blood cells. The 19th International Symposium on Blood Transfusion focused on hereditary disease and blood transfusion, demonstrating the relevance and importance of transfusion medicine. Gene therapy, whether for short-term effect or long-term support, will increase the safety, dignity and quality of life for a group of patients with diseases, abnormalities and handicaps that have hitherto only been supported and palliated. §Audience: Essential reading for haematologists, Blood Bank specialists, pharmaceutical companies and health care professionals.
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