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Kinetics of Amoxycillin and Clavulanate degradation
Engels
203 b
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Amoxycillin in combination with clavulanic acid a lactamase inhibitor is one of the most widely prescribed antibiotics.It is mainly formulated in solid dosage form since its intravenous infusions has significantly lower shelf-life. There is no doubt that a parenteral preparation would have many clinical application and benefits nevertheless such a multicomponent system needs a thorough examination and understanding of phase changes and concentration variation.This book present a research work aimed at investigating the stability of amoxycillin and clavulanate in separate and combined formulations, in the liquid and frozen states. The book provides several interesting findings not previously reported. It analyses in details the kinetics of the degradation of these antibiotics susceptible to autocatalytic and hydrolytic reactions. The book also presents a detailed literature review and analysis of the related published works for a handy reference. This book is an excellent research tool for any researcher or practitioner interested in the field of pharmaceutical sciences, physical chemistry or related subjects.
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