Longevity

Why do we age - and what if aging could be changed?

For most of history, aging was treated as inevitable: the body wears out, the clock runs down, and nothing can be done about it. Biology has spent the past half century dismantling that assumption, cell by cell.

Longevity: The Science of Aging and How to Change It presents the most important findings from the biology of aging - a field that has moved, in a single generation, from describing what happens as we age to identifying the specific molecular mechanisms that drive it, and from identifying those mechanisms to developing the first interventions capable of targeting them.

You will discover why different species age at such dramatically different rates - and what this tells us about the genetic regulation of aging. You will understand the twelve hallmarks of aging: genomic instability, telomere shortening, epigenetic drift, proteostatic failure, senescent cell accumulation, mitochondrial dysfunction, and the others that collectively produce biological decline. You will learn why cellular senescence, NAD+ depletion, and mTOR dysregulation are targets for the most promising pharmacological longevity interventions now entering clinical trials. And you will find the practical framework - grounded in the same biology that the drugs are targeting - for what exercise, nutrition, sleep, and stress management do at the molecular level, and why they remain the most powerful longevity tools available today.

The science of living longer has become one of the most actively funded and rapidly advancing areas of biology. This book is where it begins.