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Nucleic Acids
A Natural Target for Newly Designed Metal Chelate Based Drugs
Engels
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Human diseases are becoming more costly to treat and the resistance offered by disease-causing agents continues to increase and change. The abundance of drugs in the market has provided great relief to patients but the side effects can destroy the immune system of the body and are not cost-effective. The patient needs to boost their immune system and at the same time must cover the expenses incurred to cure the disease. Thus, a paradigm shift is needed to design a drug molecule with low cost and easy availability. The metal complexes can be a great example of such a shift, as metal ions are components of biological molecules and can achieve good binding capability to specific targets, while not allowing them to damage the healthy cell system. Therefore, in this book a comprehensive compilation of recent data is provided, including the structural elucidation of metal complexes by advanced techniques, the binding pattern of metal complexes with specific targets, as well as non-specific targets have been extensively discussed. Focuses on the recent advances and methods adopted for generating new metal-based molecules and their interactions with biomolecules, especially nucleic acids Addresses challenges for developing new metal-based drugs Examines advances in optical techniques for the characterization of metal-based drugs
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