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Pain is one of the most commonly experienced symptoms in dentistry and, as such, is a major concern to the dentist. Pain is an unpleasant experience that perhaps motivates the individual far greater than any other life experience the pain management is an integral aspect in endodontic treatment, the practice of endodontics requires a thorough understanding of pain mechanisms as well as management. In this book, various treatment modalities have been elaborated on in detail about the management of pain.